15692 Results for "

Fissistigma balansae (A. DC.) Merr.

" in MedChemExpress (MCE) Product Catalog:
Products (15692)

15692 Results for "Fissistigma balansae (A. DC.) Merr." in MCE Product Catalog:

815
Bafilomycin A1
Bafilomycin A1
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815 Publications Verification
Cat. No.: HY-100558
CAS No.: 88899-55-2
Purity:  99.95%
Synonyms: BafA1
Category:  

Infection Microorganisms Macrolide Antibiotics Antibiotics Disease Research Anticancer Disease Research Fields

Target:  

Proton Pump Autophagy Antibiotic Bacterial Apoptosis

Bafilomycin A1 (BafA1) is a specific and reversible inhibitor of vacuolar H +-ATPase (V-ATPase) with IC50 values of 4-400 nmol/mg. Bafilomycin A1, a macrolide antibiotic, is also used as an autophagy inhibitor at the late stage. Bafilomycin A1 blocks autophagosome-lysosome fusion and inhibits acidification and protein degradation in lysosomes of cultured cells. Bafilomycin A1 induces apoptosis .
193
Cyclosporin A
Cyclosporin A
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193 Cited Publications
Cat. No.: HY-B0579
CAS No.: 59865-13-3
Synonyms: Cyclosporine A; Ciclosporin A; CsA
Category:  

Natural Products Microorganisms Anti-aging Disease Research Fields Inflammation/Immunology Cancer

Target:  

Molecular Glues Complement System Antibiotic Cyclophilin

Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC50 of 5 nM . Cyclosporin A is a molecular glue, binds to cyclophilin and calcineurin, leading to inactivation of nuclear Factor of activated T Cells (NFAT) and a subsequent decrease in the immune response. Cyclosporin A also inhibits CD11a/CD18 adhesion .
186
Trichostatin A
Trichostatin A
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186 Cited Publications
Cat. No.: HY-15144
CAS No.: 58880-19-6
Purity:  99.53%
Synonyms: TSA
Category:  

Anti-aging Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Cancer

Target:  

Organoid HDAC

Trichostatin A (TSA) is a potent and specific inhibitor of HDAC class I/II, with an IC50 value of 1.8 nM for HDAC .
156
Brefeldin A
Brefeldin A
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156 Cited Publications
Cat. No.: HY-16592
CAS No.: 20350-15-6
Synonyms: BFA; Cyanein; Decumbin
Category:  

Infection Microorganisms Macrolide Antibiotics Antibiotics Antiviral Disease Research Anticancer Disease Research Fields

Target:  

Autophagy Mitophagy HSV Antibiotic Bacterial

Brefeldin A (BFA) is a lactone antibiotic and a specific inhibitor of protein trafficking. Brefeldin A blocks the transport of secreted and membrane proteins from endoplasmic reticulum to Golgi apparatus . Brefeldin A is also an autophagy and mitophagy inhibitor . Brefeldin A inhibits HSV-1 and has anti-cancer activity .
134
A 83-01
A 83-01
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134 Cited Publications
Cat. No.: HY-10432
CAS No.: 909910-43-6
Purity:  99.33%
Target:  

Organoid TGF-β Receptor

Research Areas:  

Cancer

A 83-01 is a potent inhibitor of TGF-β type I receptor ALK5 kinase, type I nodal receptor ALK4 and type I nodal receptor ALK7, with IC50s of 12 nM, 45 nM and 7.5 nM against the transcription induced by ALK5, ALK4 and ALK7, respectively .
134
A 83-01 sodium
A 83-01 sodium
0 Images
134 Cited Publications
Cat. No.: HY-10432A
CAS No.: 2828431-89-4
Purity:  98.43%
Target:  

Organoid TGF-β Receptor

Research Areas:  

Cancer

A 83-01 sodium is a potent inhibitor of TGF-β type I receptor ALK5 kinase, ALK4 and ALK7, with IC50s of 12 nM, 45 nM and 7.5 nM against the transcription induced by ALK5, ALK4 and ALK7, respectively .
106
A-485
A-485
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106 Cited Publications
Cat. No.: HY-107455
CAS No.: 1889279-16-6
Purity:  99.87%
Target:  

Epigenetic Reader Domain Histone Acetyltransferase

Research Areas:  

Cancer

A-485, a chemical probe, is a potent and selective catalytic inhibitor of p300/CBP with IC50s of 9.8 nM and 2.6 nM for p300 and CBP histone acetyltransferase (HAT), respectively .
99
GSK126
GSK126
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99 Cited Publications
Cat. No.: HY-13470
CAS No.: 1346574-57-9
Purity:  99.76%
Synonyms: GSK2816126A
Target:  

Histone Methyltransferase

Research Areas:  

Cancer

GSK126 (GSK2816126A) is a potent, highly selective inhibitor of EZH2 methyltransferase with an IC50 of 9.9 nM .
81
Dabrafenib
Dabrafenib
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81 Cited Publications
Cat. No.: HY-14660
CAS No.: 1195765-45-7
Purity:  99.94%
Synonyms: GSK2118436A; GSK2118436
Target:  

Raf CDK

Research Areas:  

Cancer

Dabrafenib (GSK2118436A) is an ATP-competitive inhibitor of Raf with IC50s of 5 nM and 0.6 nM for C-Raf and B-Raf V600E, respectively .
69
Nutlin-3a
Nutlin-3a
0 Images
69 Cited Publications
Cat. No.: HY-10029
CAS No.: 675576-98-4
Purity:  99.00%
Synonyms: Rebemadlin
Target:  

MDM-2/p53 E1/E2/E3 Enzyme Autophagy Apoptosis

Research Areas:  

Cancer

Nutlin-3a (Rebemadlin), an active enantiomer of Nutlin-3, is a potent murine double minute (MDM2) inhibitor (IC50=90 nM). Nutlin-3a inhibits MDM2-p53 interactions and stabilizes the p53 protein, and induces cell autophagy and apoptosis. Nutlin-3a has the potential for the study of TP53 wild-type ovarian carcinomas .
59
Pepstatin
Pepstatin
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59 Cited Publications
Cat. No.: HY-P0018
CAS No.: 26305-03-3
Synonyms: Pepstatin A
Category:  

Natural Products Microorganisms Disease Research Fields Cancer

Target:  

HIV Protease Autophagy

Pepstatin (Pepstatin A) is a specific, orally active aspartic protease inhibitor produced by actinomycetes, with IC50s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin also inhibits HIV protease .
59
Pepstatin Trifluoroacetate
Pepstatin Trifluoroacetate
0 Images
59 Cited Publications
Cat. No.: HY-P0018A
Synonyms: Pepstatin A Trifluoroacetate
Category:  

Infection Natural Products Microorganisms Disease Research Fields

Target:  

HIV Protease Autophagy

Pepstatin (Pepstatin A) Trifluoroacetate is a specific, orally active aspartic protease inhibitor produced by actinomycetes, with IC50s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin Trifluoroacetate also inhibits HIV protease .
59
Pepstatin Ammonium
Pepstatin Ammonium
0 Images
59 Cited Publications
Cat. No.: HY-P0018B
Synonyms: Pepstatin A Ammonium
Category:  

Infection Natural Products Microorganisms Disease Research Fields

Target:  

HIV Protease Autophagy

Pepstatin (Pepstatin A) Ammonium is a specific, orally active aspartic protease inhibitor produced by actinomycetes, with IC50s of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. Pepstatin Ammonium also inhibits HIV protease .
55
A-1331852
A-1331852
0 Images
55 Cited Publications
Cat. No.: HY-19741
CAS No.: 1430844-80-6
Target:  

Bcl-2 Family

Research Areas:  

Cancer

A-1331852 is an orally available BCL-XL selective inhibitor with a Ki of less than 10 pM.
53
Plicamycin
Plicamycin
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53 Cited Publications
Cat. No.: HY-A0122
CAS No.: 18378-89-7
Synonyms: Mithramycin A
Target:  

DNA/RNA Synthesis Bacterial Antibiotic Glutathione S-transferase

Research Areas:  

Infection Cancer

Plicamycin (Mithramycin A) is a selective specificity protein 1 (Sp1) inhibitor. Plicamycin inhibits the growth of various cancers by decreasing Sp1 protein. Plicamycin inhibits GSTM2 promoter activity and protein expression .
52
Oligomycin A
Oligomycin A
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52 Cited Publications
Cat. No.: HY-16589
CAS No.: 579-13-5
Synonyms: MCH 32
Category:  

Infection Microorganisms Macrolide Antibiotics Antifungal Antibiotics Disease Research Disease Research Fields

Target:  

ATP Synthase Fungal Antibiotic

Oligomycin A (MCH 32), created by Streptomyces, acts as a mitochondrial F0F1-ATPase inhibitor, with a Ki of 1 μM; Oligomycin A shows anti-fungal activity.
46
Urolithin A
Urolithin A
0 Images
46 Cited Publications
Cat. No.: HY-100599
CAS No.: 1143-70-0
Purity:  99.82%
Category:  

Human Gut Microbiota Metabolites Microorganisms Monophenols Anti-aging Phenols Polyphenols Endogenous metabolite Disease Research Fields Cancer

Target:  

Drug Metabolite Reactive Oxygen Species (ROS) DNA/RNA Synthesis Autophagy Apoptosis Endogenous Metabolite

Urolithin A, a gut-microbial metabolite of ellagic acid, exerts anti-inflammatory, antiproliferative, and antioxidant properties. Urolithin A induces autophagy and apoptosis, suppresses cell cycle progression, and inhibits DNA synthesis .
46
Streptomycin
Streptomycin
0 Images
46 Cited Publications
Cat. No.: HY-B1906
CAS No.: 57-92-1
Synonyms: Agrept; Agrimycin; Streptomycin A
Category:  

Microorganisms

Target:  

Environmental Pollutants Antibiotic Bacterial

Streptomycin (Agrept) is an effective antibiotic against M. tuberculosis, is used for the research of tuberculosis (TB). Streptomycin also is a bacteriocidal agent that can be used for the research of a number of bacterial infections. Streptomycin can bind strongly to nucleic acids, interferes and blocks protein synthesis while permitting continued RNA and DNA synthesis. Streptomycin, as a common antibiotic used in culture media, also is a blocker of stretch-activated and mechanosensitive ion channels in neurons and cardiac myocytes .
43
GSK2837808A
GSK2837808A
0 Images
43 Cited Publications
Cat. No.: HY-100681
CAS No.: 1445879-21-9
Purity:  99.24%
Target:  

Lactate Dehydrogenase

Research Areas:  

Cancer

GSK2837808A is a potent and selective lactate dehydrogenase A (LDHA) inhibitor with IC50s of 2.6 and 43 nM for hLDHA and hLDHB, respectively.
42
A-769662
A-769662
0 Images
42 Cited Publications
Cat. No.: HY-50662
CAS No.: 844499-71-4
Target:  

AMPK

Research Areas:  

Metabolic Disease

A-769662 is a AMP-activated protein kinase (AMPK) activator. A-769662 inhibits the function of the 26S proteasome by an AMPK-independent mechanism and leads to cell cycle arrest. A-769662 directly stimulates partially purified rat liver AMPK (EC50 = 0.8 μM) and inhibits fatty acid synthesis in primary rat hepatocytes (IC50 = 3.2 μM). A-769662 can alleviate the symptoms of metabolic diseases such as type 2 diabetes .
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